On June 22, Merck announced that Erbitux® (cetuximab injection) was officially approved by the China National Medical Products Administration (NMPA) for the treatment of locally
Due to the advantages of clear targets, mature technology and good selectivity, the research of antibody-drug conjugates is expected to continue to become a research
The steps of ADC drug pharmacy include: Production of Linkers and Small Molecule Drugs as Drug Intermediates Conjugating linker-small molecule intermediates to antibodies Remove unlinked
1. Directional coupling technology The ADC drugs currently in the forefront of the development all use traditional conjugation technology (no-specific conjugation). The biggest disadvantage is
ADC (antibody-drug conjugate) has become one of the research hotspots in the field of oncology in recent years. At the 2022 American Society of Clinical
1. Antibody molecules At present, the antibody molecules of ADC drugs often use humanized monoclonal antibodies, and the crystallizable fragment (Fc) segment is modified to
1. Circulation, ADC drugs are administered by systemic exposure, and first enter the blood system. Since the relative molecular mass of antibodies is about 150ku,
Antibody-drug conjugate (ADC) is to link a biologically active small-molecule drug to a monoclonal antibody through a chemical link, and the monoclonal antibody acts as
